OpenCGA Catalog implements a high-performance metadata database to track all files metadata, samples, families, ...
OpenCGA implements a high-performance and scalable variant NoSQL database to store and index thousands of whole genome VCF files. Performance observed show more than 2,000 whole genomes indexed a day.
Many variant operations have been implemented such as variant aggregation, stats calculation, variant annotation, export, ...
We have implemented the most advanced query engine and aggregation framework to query variants.
Indexing BAM files and calculating coverage is supported. You can efficiently query all these data through REST web services.
We have implemented a comprehensive REST API to work with Catalog and query Variants and Alignment data in a secure way. To facilitate using REST we have developed four client libraries developed in Java, Python, R and Javascript.
You can store all you clinical data in our free data model solution in Catalog. You can define your clinical variables and annotate files, samples, individuals, families or cohort. Clinical Data is indexed automatically to provide a real-time queries and aggregations analysis.
Disease Panels are fully supported and versioned.
You can define different types of Clinical Analysis. We have implemented some automatic clinical interpretation algorithms for Rare Diseases and Cancer. A Decision Support System has also been implemented in IVA.
Web based on IVA project at https://github.com/opencb/iva/tree/app/hgva
Server based on OpenCGA at https://github.com/opencb/opencga
IVA is a collaborative project that aims to integrate as many reference human studies as possible, you can contact us for feature request. If you want to contribute to the code you are more than welcome to contribute to IVA and OpenCGA
Ignacio Medina (HPCS, University of Cambridge)
Dr. Augusto Rendon (Genomics England)
Web based on IVA project at https://github.com/opencb/iva/tree/app/hgva
Server based on OpenCGA at https://github.com/opencb/opencga
IVA is a collaborative project that aims to integrate as many reference human studies as possible, you can contact us for feature request. If you want to contribute to the code you are more than welcome to contribute to IVA and OpenCGA