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In OpenCGA, secondary findings are the actionable variants for a given s= ample. And a Tier 3 is assigned to all reported events of those variants.= p>
Implementation
The implementation is based on creating a variant query by setting the s= ample, study and the list of actionable variant identifiers. Remember that = actionable variants depends on the study assembly, and it is managed by the= OpenCGA actionable variant manager. Once built the query, the second= ary findings analysis executes the query and creates reported variants with= its reported events. ACMG values are computed and a Tier 3 is assigne= d to each reported event.